Document Detail


Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis.
MedLine Citation:
PMID:  12588754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including VLDLs, VLDL remnants, IDLs, and LDLs. A deficiency of CETP is associated with increased HDL levels and decreased LDL levels, a profile that is typically antiatherogenic. Studies in rabbits, a species with naturally high levels of CETP, support the therapeutic potential of CETP inhibition as an approach to retarding atherogenesis. Studies in mice, a species that lacks CETP activity, have provided mixed results. Human subjects with heterozygous CETP deficiency and an HDL cholesterol level >60 mg/dL have a reduced risk of coronary heart disease. Evidence that atherosclerosis may be increased in CETP-deficient subjects whose HDL levels are not increased is difficult to interpret and may reflect confounding or bias. Small-molecule inhibitors of CETP have now been tested in human subjects and shown to increase the concentration of HDL cholesterol while decreasing that of LDL cholesterol and apoB. Thus, it seems important and timely to test the hypothesis in randomized trials of humans that pharmacological inhibition of CETP retards the development of atherosclerosis.
Authors:
Philip J Barter; H Bryan Brewer; M John Chapman; Charles H Hennekens; Daniel J Rader; Alan R Tall
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  23     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-17     Completed Date:  2003-03-14     Revised Date:  2009-10-08    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-7     Citation Subset:  IM    
Affiliation:
Hanson Institute and the Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia. p.barter@hri.org.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoproteins / physiology
Arteriosclerosis / blood,  etiology,  prevention & control*
Carrier Proteins / antagonists & inhibitors*,  genetics,  physiology
Cholesterol Ester Transfer Proteins
Cholesterol Esters / blood,  metabolism
Cholesterol, HDL / blood*
Confounding Factors (Epidemiology)
Glycoproteins*
Humans
Lipid Metabolism, Inborn Errors / blood,  complications,  genetics
Lipoproteins / blood,  metabolism
Sulfhydryl Compounds / therapeutic use
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/CETP protein, human; 0/Carrier Proteins; 0/Cholesterol Ester Transfer Proteins; 0/Cholesterol Esters; 0/Cholesterol, HDL; 0/Glycoproteins; 0/Lipoproteins; 0/Sulfhydryl Compounds; 0/apolipoprotein F; 0/dalcetrapib
Comments/Corrections
Comment In:
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):374-5   [PMID:  12639826 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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