| Cholesteryl ester transfer protein and its inhibition. | |
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MedLine Citation:
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PMID: 20556633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of cholesteryl esters from the atheroprotective high density lipoprotein (HDL) to the proatherogenic low density lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL) leading to lower levels of HDL but raising the levels of proatherogenic LDL and VLDL. Inhibition of CETP is considered a potential approach to treat dyslipidemia. However, discussions regarding the role of CETP-mediated lipid transfer in the development of atherosclerosis and CETP inhibition as a potential strategy for prevention of atherosclerosis have been controversial. Although many animal studies support the hypothesis that inhibition of CETP activity may be beneficial, negative phase III studies on clinical endpoints with the CETP inhibitor torcetrapib challenged the future perspectives of CETP inhibitors as potential therapeutic agents. The review provides an update on current understanding of the molecular mechanisms involved in CETP activity and its inhibition. |
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Authors:
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Olaf Weber; Hilmar Bischoff; Carsten Schmeck; Michael-Friedrich Böttcher |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-06-18 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 67 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 3139-49 Citation Subset: IM |
Affiliation:
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Bayer Healthcare AG/Bayer Schering Pharma, 42096, Wuppertal, Germany. olaf.weber@bayerhealthcare.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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chemistry,
therapeutic use* Atherosclerosis / drug therapy* Cholesterol Ester Transfer Proteins / antagonists & inhibitors*, genetics, metabolism* Clinical Trials as Topic Drug Design Humans |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol Ester Transfer Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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