| Cholesterolaemic influence of palmitic acid in the sn-1, 3 v. the sn-2 position with high or low dietary linoleic acid in healthy young men. | |
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MedLine Citation:
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PMID: 17391563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Healthy young men were fed four diets for 2 weeks each providing natural fats containing palmitic acid (16 : 0) predominantly in the sn-1, 3 position of dietary TAG or containing 16 : 0 predominantly in the sn-2 position with low or high levels of linoleic acid (18 : 2n-6). Two treatments supplied 16 : 0 in the sn-1, 3 positions from palmstearin with low (3 % energy) or high (>7 % energy) 18 : 2n-6 and two treatments supplied 16 : 0 in the sn-2 position from lard with high or low levels of 18 : 2n-6. Diets contained 30-35 % energy as fat, 7-11 % energy as 16 : 0 and moderate levels of cholesterol. Fasting serum cholesterol and lipoprotein concentrations were measured. Cholesterol fractional synthesis rate (FSR) was determined by 2H incorporation. Diets providing 16 : 0 in the sn-2 position resulted in lower fasting serum total cholesterol (TC) and a lower TC:HDL ratio than diets providing 16 : 0 in the sn-1, 3 positions. Diets with high levels of 18 : 2n-6 significantly decreased the TC:HDL ratio, reaffirming the well-known cholesterol-reducing effect of 18 : 2n-6. A lower non-esterified cholesterol FSR was observed with low dietary levels of 18 : 2n-6. No differences between dietary treatments were found for serum HDL-cholesterol, LDL-cholesterol or TAG. It is concluded that dietary fats containing 16 : 0 in the sn-2 position may result in slightly lower fasting TC than diets providing 16 : 0 in the sn-1, 3 positions, while the level of n-6 polyunsaturated fat influences endogenous cholesterol synthesis. |
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Authors:
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C E Forsythe; M A French; Y K Goh; M T Clandinin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-29 |
Journal Detail:
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Title: The British journal of nutrition Volume: 98 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-12 Completed Date: 2007-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 337-44 Citation Subset: IM |
Affiliation:
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Alberta Institute for Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol / blood* Cholesterol, Dietary / administration & dosage Cholesterol, HDL / blood Cholesterol, LDL / blood Diet Dietary Fats / administration & dosage*, analysis Energy Intake / physiology Enzyme Inhibitors / administration & dosage Humans Linoleic Acid / administration & dosage*, chemistry Lipids / blood Lipoproteins / blood Male Palmitic Acid / administration & dosage*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Enzyme Inhibitors; 0/Lipids; 0/Lipoproteins; 0/lipoprotein cholesterol; 2197-37-7/Linoleic Acid; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol; 61789-99-9/lard |
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