Document Detail

Cholesterol and violent behavior.
MedLine Citation:
PMID:  8002683     Owner:  NLM     Status:  MEDLINE    
Despite significant decreases [corrected] in the incidence of myocardial infarction, reduction of total mortality as a result of cholesterol-lowering programs has not been demonstrated. This puzzling outcome has led to several hypotheses linking cholesterol levels and mortality due to accidents, suicide, and homicide. We review the proposed explanations for increased mortality due to violent deaths. We discuss the available evidence and conclude that while there are some intriguing findings based on the well-established relationship between violent behavior and serotonin activity, the necessary link between cholesterol, serotonin, and violence has not been demonstrated. The complexity of the observed violent behaviors and their multiple determinants defies a simple explanation at the present time.
J M Santiago; J E Dalen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of internal medicine     Volume:  154     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-12     Completed Date:  1994-07-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1317-21     Citation Subset:  AIM; IM    
Department of Psychiatry, University of Arizona College of Medicine, Tucson.
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MeSH Terms
Accidents / mortality
Anticholesteremic Agents / adverse effects
Cardiovascular Diseases / mortality
Cause of Death*
Cholesterol / blood*
Serotonin / physiology
Suicide / statistics & numerical data
Reg. No./Substance:
0/Anticholesteremic Agents; 50-67-9/Serotonin; 57-88-5/Cholesterol
Comment In:
Arch Intern Med. 1995 Mar 13;155(5):543-4   [PMID:  7864712 ]
Arch Intern Med. 1995 Mar 13;155(5):544   [PMID:  7726951 ]
Arch Intern Med. 1995 May 8;155(9):985   [PMID:  7726707 ]
Erratum In:
Arch Intern Med 1994 Sep 26;154(18):2047

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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