| Cholesterol synthesis and de novo lipogenesis in premature infants determined by mass isotopomer distribution analysis. | |
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MedLine Citation:
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PMID: 15295085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Premature infants change from placental supply of mainly carbohydrates to an enteral supply of mainly lipids earlier in their development than term infants. The metabolic consequences hereof are not known but might have long-lasting health effects. In fact, knowledge of lipid metabolism in premature infants is very limited. We have quantified de novo lipogenesis and cholesterogenesis on d 3 of life in seven premature infants (birth weight, 1319 +/- 417 g; gestational age, 30 +/- 2 wk). For comparison, five healthy adult subjects were also studied. All subjects received a 12-h [1-(13)C] acetate infusion, followed by mass isotopomer distribution analysis (MIDA) on lipoprotein-palmitate and plasma unesterified cholesterol. The fraction of lipoprotein-palmitate synthesized at the end of the infusion period was 5.4 +/- 3.9% in infants, which was in the same range as found in adult subjects on a normal diet, suggesting that hepatic de novo lipogenesis is not a major contributor to fat accumulation in these premature neonates. The fractional contribution of newly synthesized cholesterol to plasma unesterified cholesterol was 7.4 +/- 1.3% after a 12-h infusion. The calculated rate of endogenous cholesterol synthesis was 31 +/- 7 mg/kg/d, a value approximately three times higher than that found in adult subjects (10 +/- 6 mg/kg/d). These results indicate that the cholesterol-synthesizing machinery is well developed in premature infants. |
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Authors:
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Lorraine N Renfurm; Robert H J Bandsma; Henkjan J Verkade; Christiaan V Hulzebos; Theo van Dijk; Theo Boer; Frans Stellaard; Folkert Kuipers; Pieter J J Sauer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-08-04 |
Journal Detail:
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Title: Pediatric research Volume: 56 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-24 Completed Date: 2005-02-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 602-7 Citation Subset: IM |
Affiliation:
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Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Hospital Groningen, 9700 RB Groningen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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pharmacokinetics Adult Carbon Isotopes / diagnostic use Cholesterol / analysis, biosynthesis* Energy Metabolism / physiology* Female Gas Chromatography-Mass Spectrometry* Humans Infant, Newborn Infant, Premature / metabolism* Male Phospholipids / analysis, biosynthesis Triglycerides / analysis, biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Carbon Isotopes; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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