| Cholesterol side-chain cleavage activity in the outer and inner zones of the adrenal cortex. | |
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MedLine Citation:
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PMID: 6546516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholesterol side-chain cleavage activity in mitochondria isolated from the outer and inner zones of the guinea pig adrenal cortex was evaluated in order to clarify the role of the zona reticularis in steroidogenesis. It was found that side-chain cleavage activity was three times higher in the outer zone. In addition, ether stress increased side-chain cleavage activity in the outer zone but not the inner zone. The concentration of total and free cholesterol was also found to be higher in the outer zone. However, when exogenous cholesterol was added to mitochondria, there was no enhancement in side-chain cleavage activity in either zone. |
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Authors:
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T Obara; C A Strott |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 118 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-03-12 Completed Date: 1984-03-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 198-205 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex
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drug effects,
enzymology* Animals Cholesterol / metabolism Cholesterol Side-Chain Cleavage Enzyme / metabolism* Dexamethasone / pharmacology Guinea Pigs Hydrocortisone / blood Male Mitochondria / enzymology* Organ Specificity Oxidoreductases / metabolism* Pregnenolone / metabolism Stress, Physiological / physiopathology |
| Chemical | |
Reg. No./Substance:
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145-13-1/Pregnenolone; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 57-88-5/Cholesterol; EC 1.-/Oxidoreductases; EC 1.14.15.6/Cholesterol Side-Chain Cleavage Enzyme |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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