| Cholesterol: a novel regulatory role in myelin formation. | |
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MedLine Citation:
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PMID: 21343408 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Myelin consists of tightly compacted membranes that form an insulating sheath around axons. The function of myelin for rapid saltatory nerve conduction is dependent on its unique composition, highly enriched in glycosphingolipids and cholesterol. Cholesterol emerged as the only integral myelin component that is essential and rate limiting for the development of CNS and PNS myelin. Experiments with conditional mouse mutants that lack cholesterol biosynthesis in oligodendrocytes revealed that only minimal changes of the CNS myelin lipid composition are tolerated. In Schwann cells of the PNS, protein trafficking and myelin compaction depend on cholesterol. In this review, the authors summarize the role of cholesterol in myelin biogenesis and myelin disease. |
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Authors:
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Gesine Saher; Susanne Quintes; Klaus-Armin Nave |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry Volume: 17 ISSN: 1089-4098 ISO Abbreviation: Neuroscientist Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504819 Medline TA: Neuroscientist Country: United States |
Other Details:
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Languages: eng Pagination: 79-93 Citation Subset: IM |
Affiliation:
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Max Planck Institute of Experimental Medicine, Neurogenetics, Göttingen, Germany. saher@em.mpg.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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