| Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition. | |
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MedLine Citation:
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PMID: 20538532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Small intestine essentially regulates cholesterol homeostasis. AIMS: To evaluate cholesterol metabolism in short bowel syndrome (SBS). METHODS: Cholesterol precursors (e.g., cholestenol, desmosterol and lathosterol) and plant sterols (campesterol and sitosterol), respective markers of cholesterol synthesis and absorption, were determined in SBS patients (n=12) an average of 31 months after weaning off parenteral nutrition and in age-matched controls (n=80). RESULTS: Among patients, serum cholesterol precursor sterol to cholesterol ratios were 2-10 times higher (P<0.0001 for each). Those without any remaining ileum had 1.2-2.8 times higher precursor sterol to cholesterol ratios than those with an ileal remnant (P<0.05 for each). Serum cholesterol concentration, campesterol/cholesterol and campesterol/sitosterol were 34-39% lower (P<0.05 for each) in relation to controls. Bile acid absorption was markedly impaired (2.4 (0.2-3.2)%). Plant sterol ratios reflected the absolute length of remaining jejunum (r=0.625-0.663), and precursor sterol ratios inversely that of ileum (r=-0.589 to 0.750, P<0.05 for all). CONCLUSION: After weaning off parenteral nutrition, patients with pediatric onset SBS continue to have marked intestinal malabsorption of bile acids and moderate cholesterol malabsorption resulting in decreased serum cholesterol despite a marked compensatory increase in cholesterol synthesis. |
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Authors:
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Mikko P Pakarinen; Annika Kurvinen; Helena Gylling; Tatu A Miettinen; Maria Pesonen; Markku Kallio; Antti I Koivusalo; Markku J Nissinen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-09 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 42 ISSN: 1878-3562 ISO Abbreviation: Dig Liver Dis Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 554-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Section of Pediatric Surgery, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. mikko.pakarinen@hus.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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metabolism Child Child, Preschool Cholesterol / biosynthesis, blood* Desmosterol / blood Humans Intestinal Absorption Intestine, Small / metabolism, pathology, physiopathology Malabsorption Syndromes / metabolism, physiopathology, therapy Parenteral Nutrition Phytosterols / blood Short Bowel Syndrome / metabolism*, pathology, physiopathology, therapy Sterols / blood Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Phytosterols; 0/Sterols; 313-04-2/Desmosterol; 57-88-5/Cholesterol; 80-99-9/lathosterol |
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