Document Detail

Cholesterol metabolism in active Crohn's disease.
MedLine Citation:
PMID:  19562284     Owner:  NLM     Status:  MEDLINE    
Hypocholesterolemia has been investigated as a typical feature of critical illness and is connected with poor prognosis. Crohn's disease is an inflammatory process and is associated with several metabolic disturbances. In recent decades clinical studies have established a link between lipid metabolism and systemic inflammation. In our study we examined the serum profile of cholesterol (total cholesterol, LDL- and HDL-cholesterol) and changes in the cholesterol absorption/synthesis process by determination of plasma non-cholesterol sterol (squalene, lathosterol, campesterol, sitosterol) concentrations. Serum concentrations of total cholesterol, LDL- and HDL-cholesterol and non-cholesterol sterols were evaluated in 24 patients with active Crohn's disease during a period of 28 days. We detected lower serum levels of total cholesterol (P < 0.001), LDL- and HDL-cholesterol (P < 0.05) in the patients with active Crohn's disease than in the control group. In addition, the patients had significantly lower plasma levels of lathosterol (P < 0.001) and higher concentrations of squalene, although without significant differences. A significant decrease of campesterol plasma levels (P < 0.001) was detected, but lower plasma concentrations of sitosterol were without statistical significance. The active phase of Crohn's disease is characterized by altered metabolism of lipids, mainly of cholesterol. Our results show abnormalities in plasma concentrations of non-cholesterol sterols and provide evidence that the process of cholesterol synthesis and absorption is altered in active Crohn's disease.
Vladimír Hrabovský; Zdenek Zadák; Vladimír Bláha; Radomír Hyspler; Tomás Karlík; Arnost Martínek; Alice Mendlová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  121     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  270-5     Citation Subset:  IM    
Intensive Care Unit, Department of Internal Medicine, Faculty Hospital Ostrava, Czech Republic.
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MeSH Terms
Cholesterol / blood*
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Crohn Disease / blood*
Intestinal Absorption / physiology
Protein-Energy Malnutrition / blood
Reference Values
Sterols / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Sterols; 57-88-5/Cholesterol

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