| Cholesterol metabolism in 8 to 12-year-old children born preterm or at term. | |
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MedLine Citation:
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PMID: 12839278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies in animals have indicated that cholesterol metabolism is susceptible to manipulation by diet and growth in early life. In humans, low birthweight has been associated with increased risk of coronary heart disease. AIM: To establish whether plasma lipids and indicators of cholesterol absorption, synthesis and breakdown differ in children born preterm and at term. METHODS: Plasma total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triacylglycerols, apolipoprotein A1, apolipoprotein B, lathosterol (indicator of cholesterol synthesis), campesterol (indicator of cholesterol absorption), 7-alpha hydroxycholesterol (indicator of cholesterol breakdown) were measured in up to 407 children born preterm and 36 children born at term. RESULTS: Children born preterm had lower cholesterol synthesis (p = 0.002) and lower cholesterol breakdown (p < 0.001) than those born at term, but their plasma cholesterol concentration was not significantly different. After adjusting for current size, birthweight and gestational age were significantly related to plasma lathosterol and 7-alpha hydroxycholesterol. However, when both birthweight and gestational age were adjusted, only gestational age remained significant. There were no significant differences in plasma campesterol between the two groups. CONCLUSION: Being born preterm may have a long-term effect on cholesterol metabolism in children 8-12 y later. Those born prematurely had lower cholesterol synthesis and breakdown, but their plasma cholesterol concentration was similar at this age. These parameters need to be studied in older cohorts. |
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Authors:
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M Mortaz; M S Fewtrell; T J Cole; A Lucas |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 92 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-07-03 Completed Date: 2003-12-10 Revised Date: 2008-11-27 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 525-30 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Dietetics, King's College London, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight
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physiology* Cardiovascular Diseases / etiology*, metabolism Child Child Development / physiology Cholesterol / metabolism* Cohort Studies Female Follow-Up Studies Gestational Age* Humans Infant, Newborn Infant, Premature / metabolism* Lipids / blood Male Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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G9827821(62595)//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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