Document Detail

Cholesterol metabolism and esterases in four strains of rats with differential cholesterolemic responses to a high-cholesterol, high-cholate diet.
MedLine Citation:
PMID:  3608435     Owner:  NLM     Status:  MEDLINE    
The increase in serum cholesterol after feeding a diet containing 2% (w/w) of cholesterol and 0.5% of cholate for 13 days was 200 and 800% in two hypo- and two hyper-responsive inbred strains of rats, respectively. While remaining on the high-cholesterol, high-cholate diet for longer periods, the level of serum cholesterol dropped in the hyper-responsive strains, and after 8 weeks on the diet one hyper-responsive strain had similar serum cholesterol concentrations as the two hypo-responsive strains. The feeding of a semipurified diet, containing 1% (w/w) of cholesterol and 20% of fat, did not discriminate between the two hypo- and hyper-responsive strains with respect to the response of serum cholesterol. The activities in plasma of the indicators for liver function, aspartate amino transferase and alkaline phosphatase, were significantly increased in all strains after feeding the high-cholesterol, high-cholate diet. Only alkaline phosphatase was increased by the semipurified diet. Evidence is presented that in the four inbred strains of rats the differential cholesterolemic response to the high-cholesterol, high-cholate diet is not related to the baseline serum lipoprotein profile, liver cholesterol accumulation, fecal bile acid excretion, and the total activities and patterns of esterases in serum, liver and small intestine.
A C Beynen; A G Lemmens; M B Katan; J J De Bruijne; L F Van Zutphen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  87     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1987  
Date Detail:
Created Date:  1987-08-31     Completed Date:  1987-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
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MeSH Terms
Body Weight
Cholesterol / blood*,  metabolism
Cholesterol, Dietary / administration & dosage*
Cholesterol, LDL / blood
Cholic Acid
Cholic Acids / administration & dosage*
Electrophoresis, Polyacrylamide Gel
Esterases / blood*,  metabolism
Hypercholesterolemia / etiology*,  physiopathology
Lipoproteins / blood,  classification
Liver / analysis
Liver Diseases / etiology
Rats, Inbred Strains
Species Specificity
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Cholesterol, LDL; 0/Cholic Acids; 0/Lipoproteins; 57-88-5/Cholesterol; 81-25-4/Cholic Acid; EC 3.1.-/Esterases

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