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Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130).
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MedLine Citation:
PMID:  1419621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of cholesterol has been investigated in tumour cells, ascitic fluid and blood serum during the growth of an ascites hepatoma (Yoshida AH-130) in the rat. High rates of cholesterol synthesis and elevated free and esterified cholesterol content were observed in tumour cells. During tumour growth, the host animals progressively developed marked changes in the level and distribution of serum cholesterol consisting in an increase of total cholesterol and of a marked reduction of HDL cholesterol (HDL2 subfraction in particular). In agreement with previous observations, these findings indicate that a consistent pattern of altered cholesterol homeostasis develops in relation to normal or neoplastic tissue growth. High synthetic rates and intracellular accumulation of cholesterol are observed in the proliferating cells. Moreover, blood serum cholesterol decreases in the HDL fraction while it increases in LDLs, suggesting that during proliferative processes cholesterol fluxes between tissues and serum lipoproteins are markedly perturbed.
Authors:
S Dessí; B Batetta; C Anchisi; P Pani; P Costelli; L Tessitore; F M Baccino
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of cancer     Volume:  66     ISSN:  0007-0920     ISO Abbreviation:  Br. J. Cancer     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-15     Completed Date:  1992-12-15     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0370635     Medline TA:  Br J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  787-93     Citation Subset:  IM    
Affiliation:
Istituto di Patologia Sperimentale, Università degli Studi di Cagliari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ascites / metabolism
Blood Proteins / metabolism
Body Weight / physiology
Cell Division / physiology
Cholesterol / biosynthesis,  blood,  metabolism*
Chromatography, High Pressure Liquid
DNA, Neoplasm / biosynthesis
Lipids / blood
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Liver Neoplasms, Experimental / metabolism*,  pathology
Male
Molecular Weight
Neoplasm Proteins / metabolism
Neoplasm Transplantation
Rats
Rats, Wistar
Thymidine / metabolism
Time Factors
Tritium
Tumor Necrosis Factor-alpha / metabolism
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/DNA, Neoplasm; 0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Neoplasm Proteins; 0/Tumor Necrosis Factor-alpha; 10028-17-8/Tritium; 50-89-5/Thymidine; 57-88-5/Cholesterol
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Br J Cancer
ISSN: 0007-0920
ISSN: 1532-1827
Article Information
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Print publication date: Month: 11 Year: 1992
Volume: 66 Issue: 5
First Page: 787 Last Page: 793
ID: 1977989
PubMed Id: 1419621

Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130).
S. Dessí
B. Batetta
C. Anchisi
P. Pani
P. Costelli
L. Tessitore
F. M. Baccino
Istituto di Patologia Sperimentale, Università degli Studi di Cagliari, Italy.



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