Document Detail


Cholesterol lowering with bile salt hydrolase-active probiotic bacteria, mechanism of action, clinical evidence, and future direction for heart health applications.
MedLine Citation:
PMID:  23350815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Cardiovascular diseases (CVD) are the leading cause of global mortality and morbidity. Current CVD treatment methods include dietary intervention, statins, fibrates, niacin, cholesterol absorption inhibitors, and bile acid sequestrants. These formulations have limitations and, thus, additional treatment modalities are needed. Probiotic bacteria, especially bile salt hydrolase (BSH)-active probiotic bacteria, have demonstrated cholesterol-lowering efficacy in randomized controlled trials.
AREAS COVERED: This review describes the current treatments for CVD and the need for additional therapeutics. Gut microbiota etiology of CVD, cholesterol metabolism, and the role of probiotic formulations as therapeutics for the treatment and prevention of CVD are described. Specifically, we review studies using BSH-active bacteria as cholesterol-lowering agents with emphasis on their cholesterol-lowering mechanisms of action. Potential limitations and future directions are also highlighted.
EXPERT OPINION: Numerous clinical studies have concluded that BSH-active probiotic bacteria, or products containing them, are efficient in lowering total and low-density lipoprotein cholesterol. However, the mechanisms of action of BSH-active probiotic bacteria need to be further supported. There is also the need for a meta-analysis to provide better information regarding the therapeutic use of BSH-active probiotic bacteria. The future of BSH-active probiotic bacteria most likely lies as a combination therapy with already existing treatment options.
Authors:
Mitchell L Jones; Catherine Tomaro-Duchesneau; Christopher J Martoni; Satya Prakash
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-28
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  13     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-08     Completed Date:  2013-09-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  631-42     Citation Subset:  IM    
Affiliation:
Micropharma Ltd, 141 avenue du President Kennedy, UQAM Biological Sciences Building, 5th Floor, Suite 5569 Montreal, Quebec, H2X 3Y7, Canada.
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MeSH Terms
Descriptor/Qualifier:
Amidohydrolases / chemistry*
Animals
Anticholesteremic Agents*
Cholesterol / metabolism*
Gastrointestinal Tract / microbiology
Heart Diseases / microbiology,  prevention & control*
Humans
Hypercholesterolemia / drug therapy
Hyperlipidemias / drug therapy
Metagenome
Probiotics / chemistry*,  therapeutic use*
Grant Support
ID/Acronym/Agency:
MPO 64308//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 57-88-5/Cholesterol; EC 3.5.-/Amidohydrolases; EC 3.5.1.24/choloylglycine hydrolase

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