Document Detail

Cholesterol lowering and the reduction of CHD incidence and total mortality: results from a meta-analysis of randomized trials.
MedLine Citation:
PMID:  1390319     Owner:  NLM     Status:  MEDLINE    
This editorial reports on a meta-analysis done on cholesterol-lowering trials. Coronary heart disease incidence is reported for 16 trials and total mortality for 19 trials. The cholesterol benefit ratio, i.e., the percent risk reduction divided by the percent cholesterol reduction, was analyzed in terms of total vs. potential modifying factors. For coronary heart disease the benefit ratio was 2.8 (95% CL: 1.5, 4.2), and for total mortality it was 1.2 (95% CL: -0.1, 2.3). Cholesterol reduction had to be at least 8-9% to outweigh the negative impact of treatment on total mortality.
I Holme
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Publication Detail:
Type:  Editorial    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  6     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-11-10     Completed Date:  1992-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-2     Citation Subset:  IM    
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MeSH Terms
Cholesterol / blood*
Coronary Disease / mortality,  prevention & control*
Meta-Analysis as Topic
Randomized Controlled Trials as Topic
Reg. No./Substance:

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