| Cholesterol-lowering nutraceuticals and functional foods. | |
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MedLine Citation:
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PMID: 18778072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological studies have demonstrated that elevated levels of plasma total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are the major risk factors for coronary heart disease (CHD), whereas high concentrations of plasma high-density lipoprotein cholesterol (HDL-C) and a low ratio of TC to HDL-C are protective against CHD. A relationship between plasma TC and the risk of CHD is well established at concentrations above 240 mg/dL. In addition to the use of three main classes of cholesterol-lowering medications, including HMG-CoA reductase inhibitors, anion-exchange resins, and fibrates, a nutritionally balanced diet that reduces saturated fat and cholesterol intake has traditionally been the first goal of dietary therapy in lowering plasma TC. In recent years, nutraceuticals and functional foods have attracted much interest as possible alternative therapies for lowering plasma TC, especially for hypercholesterolemia patients, whose blood cholesterol level is marginally high (200-240 mg/dL) but not high enough to warrant the prescription of cholesterol-lowering medications. This review summarizes the findings of recent studies on the production, application, efficacy, and mechanisms of popular cholesterol-lowering nutraceuticals and functional foods. |
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Authors:
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Zhen-Yu Chen; Rui Jiao; Ka Ying Ma |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-09-09 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 56 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-03 Completed Date: 2008-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 8761-73 Citation Subset: IM |
Affiliation:
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Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, China. zhenyuchen@cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / therapeutic use Catechin / therapeutic use Cultured Milk Products Dietary Fiber / therapeutic use Dietary Supplements* Fagopyrum Flavonoids / therapeutic use Garlic Humans Hypercholesterolemia / diet therapy*, drug therapy Naphthalenes / therapeutic use Oryza sativa Phenols / therapeutic use Phytoestrogens / therapeutic use Phytosterols / therapeutic use Tea |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Flavonoids; 0/Naphthalenes; 0/Phenols; 0/Phytoestrogens; 0/Phytosterols; 0/Tea; 0/polyphenols; 154-23-4/Catechin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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