Document Detail


Cholesterol lowering effects of rhubarb stalk fiber in hypercholesterolemic men.
MedLine Citation:
PMID:  9430089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The present study was undertaken to examine the lipid lowering effects of rhubarb fiber prepared by blanching and drying fresh rhubarb stalks. The new fiber source contained 74% dietary fiber, on dry weight basis, with 66% insoluble and 8% soluble fiber. DESIGN: Ten hypercholesterolemic men were assigned to consume 27 g of ground rhubarb stalk fiber per day for 4 weeks. The dietary intake in terms of total energy, lipid and cholesterol was kept unaltered during the study period. Changes in serum lipid profile were monitored by obtaining blood samples before and after the fiber intervention. RESULTS: Rhubarb fiber supplementation resulted in significant lowering of serum total cholesterol (8%) and low-density lipoprotein (LDL) cholesterol (9%), while high-density lipoprotein cholesterol (HDL) concentrations remained unchanged. The depressed total and LDL cholesterol levels returned to baseline after the fiber supplementation was withdrawn for 1 month. CONCLUSION: The rhubarb stalk fiber is effective in lowering serum cholesterol concentrations, especially LDL cholesterol, in hypercholesterolemic men. These results signify the potential use of underutilized rhubarb crop.
Authors:
V Goel; B Ooraikul; T K Basu
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  16     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  600-604     Citation Subset:  IM    
Affiliation:
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Cholesterol / blood*
Cholesterol, HDL / blood,  drug effects
Cholesterol, LDL / blood,  drug effects
Diet, Fat-Restricted*
Dietary Fiber / administration & dosage,  therapeutic use*
Energy Intake / drug effects,  physiology
Humans
Hypercholesterolemia / diet therapy*
Male
Middle Aged
Plants, Medicinal*
Rheum*
Time Factors
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 57-88-5/Cholesterol

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