| Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia. | |
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MedLine Citation:
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PMID: 1319110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Psyllium hydrophilic mucilloid, rich in soluble fiber, significantly lowers serum cholesterol concentrations. To investigate the lipid-lowering effects of a ready-to-eat cereal enriched with psyllium, we studied 44 hypercholesterolemic ambulatory individuals for 7 wk, using a randomized, double-blind, parallel design. After a 1-wk baseline period, subjects were randomly assigned to consume 114 g/d of a psyllium-flake or wheat-bran-flake cerearl for 6 wk adjunctive to an American Heart Association Step I diet. Serum high-density-lipoprotein cholesterol and triglycerides remained unchanged throughout the study; however, serum cholesterol and low-density lipoprotein (LDL) concentrations were significantly lower on psyllium than on wheat-bran cereal. Additionally, serum total and LDL cholesterol values were significantly lower than baseline values in the psyllium group. The dietary nutrient intake of the two groups did not differ except for soluble fiber. Adding psyllium-enriched cereal to a prudent low-fat diet may enhance dietary management of hypercholesterolemia. |
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Authors:
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J W Anderson; S Riddell-Mason; N J Gustafson; S F Smith; M Mackey |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 56 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-07-23 Completed Date: 1992-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 93-8 Citation Subset: AIM; IM |
Affiliation:
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Metabolic Research Group, University of Kentucky, Lexington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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administration & dosage,
therapeutic use* Apolipoprotein A-I / analysis Apolipoproteins B / blood Body Weight Cereals Chemotherapy, Adjuvant Cholesterol, LDL / blood Dietary Fats / administration & dosage Dietary Fiber / administration & dosage, therapeutic use Double-Blind Method Female Humans Hypercholesterolemia / diet therapy, drug therapy* Male Patient Compliance Psyllium / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Cholesterol, LDL; 0/Dietary Fats; 8063-16-9/Psyllium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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