| Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 12824094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Tea consumption has been associated with decreased cardiovascular risk, but potential mechanisms of benefit are ill-defined. While epidemiologic studies suggest that drinking multiple cups of tea per day lowers low-density lipoprotein cholesterol (LDL-C), previous trials of tea drinking and administration of green tea extract have failed to show any impact on lipids and lipoproteins in humans. Our objective was to study the impact of a theaflavin-enriched green tea extract on the lipids and lipoproteins of subjects with mild to moderate hypercholesterolemia. METHODS: Double-blind, randomized, placebo-controlled, parallel-group trial set in outpatient clinics in 6 urban hospitals in China. A total of 240 men and women 18 years or older on a low-fat diet with mild to moderate hypercholesterolemia were randomly assigned to receive a daily capsule containing theaflavin-enriched green tea extract (375 mg) or placebo for 12 weeks. Main outcome measures were mean percentage changes in total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglyceride levels compared with baseline. RESULTS: After 12 weeks, the mean +/- SEM changes from baseline in total cholesterol, LDL-C, HDL-C, and triglyceride levels were -11.3% +/- 0.9% (P =.01), -16.4% +/- 1.1% (P =.01), 2.3% +/- 2.1% (P =.27), and 2.6% +/- 3.5% (P =.47), respectively, in the tea extract group. The mean levels of total cholesterol, LDL-C, HDL-C, and triglycerides did not change significantly in the placebo group. No significant adverse events were observed. CONCLUSION: The theaflavin-enriched green tea extract we studied is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated. |
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Authors:
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David J Maron; Guo Ping Lu; Nai Sheng Cai; Zong Gui Wu; Yue Hua Li; Hui Chen; Jian Qiu Zhu; Xue Juan Jin; Bert C Wouters; Jian Zhao |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of internal medicine Volume: 163 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-25 Completed Date: 2003-07-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 1448-53 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. david.maron@vanderbilt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biflavonoids* Catechin / therapeutic use Cholesterol / blood Cholesterol, LDL / blood* Diet, Fat-Restricted Double-Blind Method Female Humans Hypercholesterolemia / blood, diet therapy, drug therapy* Male Middle Aged Plant Extracts / therapeutic use Tea* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biflavonoids; 0/Cholesterol, LDL; 0/Plant Extracts; 0/Tea; 0/Triglycerides; 154-23-4/Catechin; 4670-05-7/theaflavin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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