Document Detail

Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial.
MedLine Citation:
PMID:  10593347     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the efficacy of stanol esters in lowering cholesterol in a US population.
SUBJECTS AND METHODS: After a run-in phase, 318 subjects were randomized to receive one of the following margarine-like spreads containing stanol ester or placebo for 8 weeks: EU 3 G: 1 g of stanol (ester form) per 8-g serving of a European formula 3 times a day; US 3 G: 1 g of stanol (ester form) per 8-g serving of a US reformulation 3 times a day; US 2 G: 0.67 g of stanol (ester form) per 8-g serving of a US reformulation 3 times a day; or placebo spread.
RESULTS: Mean +/- SD baseline total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were 233+/-20 and 153+21 mg+/-dL, respectively. In the US 3 G group, 3 g daily of stanol esters lowered TC and LDL-C levels by 6.4% and 10.1%, respectively. There was a dose-dependent response compared with 2 g daily (US 2 G). Triglyceride and high-density lipoprotein cholesterol levels were unchanged. The incidence of adverse effects was not different from placebo. Serum vitamin A and 25-hydroxyvitamin D levels were not affected.
CONCLUSIONS: Stanol esters lowered TC and LDL-C levels in a mildly hypercholesterolemic US population without evidence of adverse effects. It may be a useful dietary adjunct to lower cholesterol.
T T Nguyen; L C Dale; K von Bergmann; I T Croghan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  74     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-29     Completed Date:  1999-12-29     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1198-206     Citation Subset:  AIM; IM    
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MeSH Terms
Anticholesteremic Agents / administration & dosage,  pharmacology*
Cholestanols / metabolism*
Cholesterol / analogs & derivatives,  blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Dietary Fats / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Double-Blind Method
Esters / administration & dosage,  pharmacology
Hypercholesterolemia / blood,  diet therapy,  drug therapy*
Middle Aged
Phytosterols / administration & dosage,  blood,  pharmacology*
Sitosterols / blood
Treatment Outcome
Triglycerides / blood
United States
Vitamin A / blood
Vitamin D / analogs & derivatives,  blood
beta Carotene / blood
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholestanols; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Esters; 0/Phytosterols; 0/Sitosterols; 0/Triglycerides; 01YAE03M7J/beta Carotene; 11103-57-4/Vitamin A; 1406-16-2/Vitamin D; 5J08LF99N1/campestanol; 5L5O665639/campesterol; 5LI01C78DD/gamma-sitosterol; 64719-49-9/25-hydroxyvitamin D; 80-99-9/lathosterol; 97C5T2UQ7J/Cholesterol; C2NJ9WO6O7/stigmastanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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