| Cholesterol lowering effect of SG-GN3, the extract of salted and fermented small shrimps, Acetes japonicus, in Triton WR-1339 or high cholesterol-diet induced hypercholesterolemic rats. | |
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MedLine Citation:
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PMID: 15120444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cholesterol lowering effect of SG-GN3, the extract of salted and fermented small shrimps, Acetes japonicus, was investigated in hypercholesterolemic animal models. Hypercholesterolemia was induced with Triton WR-1339 (nonionic detergent) or high cholesterol (HC)-diet. SG-GN3 significantly decreased total cholesterol (TC) in Triton WR-1339 model at 30 post-treatment hour (549.80 +/- 152.46 mg/dl) compared to the control which induced by only Triton WR-1339 (798.84 +/- 94.98 mg/dl), whereas high-density lipoprotein (HDL) content did not decrease (P < 0.05). In HC-diet model, TC content significantly decreased by SG-GN3 treatment at 3 post-treatment day (P < 0.05). These results suggest that SG-GN3 effectively decreased serum TC level in hypercholesterolemic animal models. |
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Authors:
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Seung-Hyeok Seok; Jong-Hwan Park; Sun-A Cho; Song-Am Choi; Jae-Hak Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 91 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-05-03 Completed Date: 2004-08-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 231-5 Citation Subset: IM |
Affiliation:
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Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / administration & dosage, pharmacology*, therapeutic use Cholesterol / blood Cholesterol, Dietary Cholesterol, HDL / blood Cholesterol, LDL / blood Complex Mixtures / administration & dosage, pharmacology*, therapeutic use Crustacea* Disease Models, Animal Hypercholesterolemia / chemically induced, prevention & control* Male Phytotherapy* Polyethylene Glycols / diagnostic use Random Allocation Rats Rats, Sprague-Dawley Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Complex Mixtures; 0/Polyethylene Glycols; 0/SG-GN3; 0/Triglycerides; 25301-02-4/tyloxapol; 57-88-5/Cholesterol |
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