Document Detail


Cholesterol levels linked to abnormal plasma thiol concentrations and thiol/disulfide redox status in hyperlipidemic subjects.
MedLine Citation:
PMID:  14607527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of hyperlipidemic patients with the thiol compound N-acetylcysteine (NAC) was previously shown to cause a significant dose-related increase in the high-density lipoprotein (HDL)-cholesterol serum level, suggesting the possibility that its disease-related decrease may result from a diminished thiol concentration and/or thiol/disulfide redox status (REDST) in the plasma. We therefore investigated plasma thiol levels and REDST in normo-/hyperlipidemic subjects with and without coronary heart disease (CHD). The thiol level, REDST, and amino acid concentrations in the plasma and intracellular REDST of peripheral blood mononuclear cells (PBMC) have been determined in 62 normo- and hyperlipidemic subjects. Thirty-three of these subjects underwent coronary angiography, because of clinical symptoms of CHD. All groups of hyperlipidemic patients under test and those normolipidemic individuals with documented coronary stenoses showed a marked decrease in plasma thiol concentrations, plasma and intracellular REDST of PBMCs, and a marked increase in plasma taurine levels. Individual plasma thiol concentrations and plasma REDST were strongly negatively correlated with the serum LDL-cholesterol and positively correlated with the serum HDL-cholesterol level. Together with the earlier report about the effect of NAC on the HDL-cholesterol serum level, our findings suggest strongly that lower HDL-cholesterol serum levels may result from a decrease in plasma thiol level and/or REDST possibly through an excessive cysteine catabolism into taurine.
Authors:
Ralf Kinscherf; Konstantinos Cafaltzis; Falk Röder; Wulf Hildebrandt; Lutz Edler; Hans Peter Deigner; Raoul Breitkreutz; Giso Feussner; Jörg Kreuzer; Egon Werle; Gerd Michel; Jürgen Metz; Wulf Dröge
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  35     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1286-92     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology III, Heidelberg University, Heidelberg, Germany. Ralf.Kinscherf@urz.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood
Cholesterol / blood
Cholesterol, HDL / blood*
Cholesterol, LDL / blood
Coronary Disease / blood*
Cysteine / blood
Disulfides / blood*
Glutathione / metabolism
Humans
Hyperlipidemias / blood*
Oxidation-Reduction*
Sulfhydryl Compounds / blood*
Taurine / blood
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Disulfides; 0/Sulfhydryl Compounds; 0/Triglycerides; 107-35-7/Taurine; 52-90-4/Cysteine; 57-88-5/Cholesterol; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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