| Cholesterol in pleural exudates depends mainly on increased capillary permeability. | |
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MedLine Citation:
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PMID: 20303466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pleural fluid (PF) cholesterol is a useful parameter to differentiate between pleural transudates and exudates, although the pathophysiologic mechanisms for its increase in exudates are not fully understood. We aim to elucidate the cause of this increase by analyzing the levels of cholesterol-high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), apolipoprotein A (ApoA), and apolipoprotein B (ApoB)-in PF and blood as well as the number of leucocytes and red cells in the PF. We studied 259 patients with pleural effusion (57 transudates and 202 exudates). The correlations of the pleural and serum (S) levels of these parameters were analyzed, with the pleural cholesterol fractions as the dependent variables and their levels in blood and the pleural/serum protein ratio (P/S prot ratio) as the independent variables. The pleural fluid cholesterol levels (PFCHOL) correlated with their blood levels and the capillary permeability (r=0.885). No significant differences were found between the percentage of LDL, with regard to total cholesterol in the serum [SCHOL], and the same percentage in the exudates, between the PF/S LDL ratio (0.46) and the PF/S CHOL ratio (0.48), or between the PF/S ApoB ratio and the PF/S LDL ratio. The percentage of PF cholesterol bound to HDL and LDL was significantly higher (91.9%) than in the blood (90%). No significant correlations were found between any of the lipids studied and the number of erythrocytes and leucocytes. In conclusion, the PFCHOL may be predicted from the SCHOL, and the capillary permeability may be reflected by the PF/S prot ratio. |
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Authors:
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Luis Vald?s; Esther San-Jos?; Juan Carlos Est?vez; Francisco Javier Gonz?lez-Barcala; Jos? Manuel Alvarez-Doba?o; Antonio Golpe; Jos? Manuel Valle; Pedro Penela; Luis Vizca?no; Antonio Pose |
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Publication Detail:
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Type: Journal Article Date: 2009-12-24 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 155 ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 178-84 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Pulmonology Department, University Clinical Hospital Complex, Santiago de Compostela, A Coru?a, Spain. luis.valdes.cuadrado@sergas.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apolipoproteins / blood Capillary Permeability / physiology* Cholesterol / blood, metabolism* Exudates and Transudates / metabolism* Female Humans Linear Models Male Middle Aged Multivariate Analysis Pleural Effusion / blood, etiology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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