Document Detail


Cholesterol imbalance in adipocytes: a possible mechanism of adipocytes dysfunction in obesity.
MedLine Citation:
PMID:  20025694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies of the past decade have increased our understanding of the role of adipose tissue dysfunction in obesity and obesity-related insulin resistance and type 2 diabetes. Although adipose tissue is the body's largest pool of free cholesterol, adipocytes have limited activity in cholesterol synthetic pathway. Thus, the majority of adipocyte cholesterol originates from circulating lipoproteins. To maintain cholesterol homeostasis, adipocytes have developed multiple pathways for cholesterol efflux. Several transcriptional factors, such as sterol regulatory element-binding proteins and liver X receptors may be responsible for the regulation of cholesterol homeostasis in adipocytes. Most notably, because altering cholesterol balance profoundly modifies adipocyte metabolism in a way resembling that seen in hypertrophied adipocytes, cholesterol imbalance is recognized as a characteristic for enlarged adipocytes per se in the obese state. In addition, plasma membrane cholesterol normalization by chromium picolinate can fully restore insulin-stimulated glucose transport, further supporting the role of the adipocyte cholesterol imbalance in obesity and insulin resistance.
Authors:
B-L Yu; S-P Zhao; J-R Hu
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-12-21
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  11     ISSN:  1467-789X     ISO Abbreviation:  Obes Rev     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  560-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / cytology,  metabolism*,  physiology
Adipose Tissue / metabolism,  physiopathology
Cholesterol / metabolism*
Homeostasis
Humans
Insulin Resistance / physiology
Lipid Metabolism
Obesity / metabolism*,  physiopathology*
Transcription Factors / metabolism
Chemical
Reg. No./Substance:
0/Transcription Factors; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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