| Cholesterol imbalance in adipocytes: a possible mechanism of adipocytes dysfunction in obesity. | |
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MedLine Citation:
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PMID: 20025694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies of the past decade have increased our understanding of the role of adipose tissue dysfunction in obesity and obesity-related insulin resistance and type 2 diabetes. Although adipose tissue is the body's largest pool of free cholesterol, adipocytes have limited activity in cholesterol synthetic pathway. Thus, the majority of adipocyte cholesterol originates from circulating lipoproteins. To maintain cholesterol homeostasis, adipocytes have developed multiple pathways for cholesterol efflux. Several transcriptional factors, such as sterol regulatory element-binding proteins and liver X receptors may be responsible for the regulation of cholesterol homeostasis in adipocytes. Most notably, because altering cholesterol balance profoundly modifies adipocyte metabolism in a way resembling that seen in hypertrophied adipocytes, cholesterol imbalance is recognized as a characteristic for enlarged adipocytes per se in the obese state. In addition, plasma membrane cholesterol normalization by chromium picolinate can fully restore insulin-stimulated glucose transport, further supporting the role of the adipocyte cholesterol imbalance in obesity and insulin resistance. |
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Authors:
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B-L Yu; S-P Zhao; J-R Hu |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-12-21 |
Journal Detail:
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Title: Obesity reviews : an official journal of the International Association for the Study of Obesity Volume: 11 ISSN: 1467-789X ISO Abbreviation: Obes Rev Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897395 Medline TA: Obes Rev Country: England |
Other Details:
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Languages: eng Pagination: 560-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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cytology,
metabolism*,
physiology Adipose Tissue / metabolism, physiopathology Cholesterol / metabolism* Homeostasis Humans Insulin Resistance / physiology Lipid Metabolism Obesity / metabolism*, physiopathology* Transcription Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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