Document Detail

Cholesterol granulomas in mice deficient in apolipoprotein E.
MedLine Citation:
PMID:  11487256     Owner:  NLM     Status:  MEDLINE    
Three 12- to 16-month-old female B6,129 apolipoprotein E-deficient mice were presented for necropsy because of bilateral masses in the gluteal region. Histopathologic examination revealed cholesterol granulomas extending from the superficial dermis to the underlying gluteal muscles. Microscopic granulomas were found on the face, perivaginal tissues, mesenteric lymph nodes, spleen, joints, kidneys, and choroid plexus. Other lesions included severe atherosclerosis of the aortic valves, aorta, pulmonary artery, and renal artery. Here we show that macroscopic cholesterol granulomas can develop in apolipoprotein E-deficient that receive a normal rodent diet.
J R Owiny; J D Strandberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science     Volume:  39     ISSN:  1060-0558     ISO Abbreviation:  Contemp Top Lab Anim Sci     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2001-08-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9204153     Medline TA:  Contemp Top Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-8     Citation Subset:  IM    
Johns Hopkins University, School of Medicine, 459 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.
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MeSH Terms
Apolipoproteins E / deficiency*
Arteriosclerosis / etiology,  pathology,  veterinary
Cholesterol / analysis*
Granuloma / etiology,  veterinary*
Grant Support
Reg. No./Substance:
0/Apolipoproteins E; 57-88-5/Cholesterol

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