| Cholesterol feeding alters the metabolism of thoracic-duct lymph lipoprotein cholesterol in rabbits but not in rats. | |
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MedLine Citation:
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PMID: 4772619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Labelled thoracic-duct lymph was collected from rats and rabbits after test meals containing [(14)C]cholesterol and [2-(3)H]glyceryl trioleate. 2. The metabolism of labelled cholesterol and triglyceride was studied in normally fed and cholesterol-fed rats and rabbits injected with radioactive lymph from the same species. 3. In normally fed animals of both species, 10min after intravenous administration, about 80% of lymph cholesteryl ester but only about 10% of triglyceride was recovered in the liver after clearance from the plasma. This distribution is consistent with participation of ;remnant' particles in the metabolism of dietary lymph particles. 4. The metabolism of cleared lymph lipoprotein constituents was unchanged in cholesterol-fed rats, but the recovery of cholesteryl ester in the livers of the cholesterol-fed rabbits was decreased to 30% of the cleared dose. 5. The low recovery in cholesterol-fed rabbits was accounted for mainly by increased hydrolysis of cholesteryl ester. 6. It is proposed that differences between rats and rabbits in metabolism of dietary cholesterol might be partly due to the observed enhancement of hydrolysis of lymph lipoprotein cholesteryl ester in rabbits. |
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Authors:
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T G Redgrave |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 136 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1973 Sep |
Date Detail:
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Created Date: 1974-03-19 Completed Date: 1974-03-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 109-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Radioisotopes Cholesterol / blood, metabolism* Cholesterol, Dietary / metabolism Esters Hydrolysis Injections, Intravenous Lipoproteins / metabolism* Liver / metabolism Lymph / metabolism* Rabbits Rats Thoracic Duct / metabolism* Triolein / metabolism Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Cholesterol, Dietary; 0/Esters; 0/Lipoproteins; 10028-17-8/Tritium; 122-32-7/Triolein; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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