Document Detail


Cholesterol esterification of mechanically-induced aortic lesions in normolipemic pigs.
MedLine Citation:
PMID:  7213025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intimal thickenings were produced in the abdominal aortae of normolipemic pigs by longitudinal mechanical injury. In two-week lesions there was increased I-14C-oleic acid incorporation into esterified cholesterol (CE), accompanied by lipid droplet formation. In twelve-week lesions, lipid droplets had largely disappeared, and the incorporation of 1-14C-oleic acid into CE was similar to that of normal aorta. Increased esterification of cholesterol with oleic acid may be a protective mechanism during the early phases of the arterial repair reaction. Regression of the lesions may be associated with the return of cholesterol esterification activity to normal.
Authors:
I H Craig; G G Jamieson; M Foldes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artery     Volume:  7     ISSN:  0098-6127     ISO Abbreviation:  Artery     Publication Date:  1980  
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508494     Medline TA:  Artery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  404-18     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / injuries,  pathology*
Cholesterol Esters / metabolism*
Lipids / blood*
Male
Muscle, Smooth, Vascular / pathology
Oleic Acids / metabolism
Swine
Time Factors
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Lipids; 0/Oleic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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