Document Detail

Cholesterol esterase activity in body fluids.
MedLine Citation:
PMID:  183807     Owner:  NLM     Status:  MEDLINE    
Antistreptolysin O activity (greater than or equal to 200 Todd units/ml) was found in 20% of 25 ascitic fluids, 20% of 55 pleural fluids and 37-5% of 56 joint fluids. These levels are not due to antibody but to the cholesterol moiety of altered beta-lipoproteins. The activity is precipitable with 10% dextran sulphate. Incubation of mixtures of fluids with titres less than 200 and normal human serum generated eight-fold or greater rises in antistreptolysin titres. This results from the activity of cholesterol esterase in the fluid acting on the beta-lipoprotein of the serum and activity was noted in 90% of ascitic fluids, 59% of pleural fluids and 54% of joint fluids. However, mixtures showing no such rise probably also contain esterase, the failure to demonstrate antistreptolysin activity being due to equilibration of ester derived cholesterol with sub-fractions of high density and very low density lipoproteins.
K C Watson; E J Kerr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  57     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  481-5     Citation Subset:  IM    
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MeSH Terms
Antistreptolysin / analysis
Ascitic Fluid / enzymology
Body Fluids / enzymology*
Carboxylic Ester Hydrolases / metabolism*
Lipoproteins, LDL / metabolism
Pleural Effusion / enzymology
Sterol Esterase / metabolism*
Synovial Fluid / enzymology
Reg. No./Substance:
0/Lipoproteins, LDL; 9006-92-2/Antistreptolysin; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC Esterase

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