Document Detail

Cholesterol embolization syndrome. Occurrence after intravenous streptokinase therapy for myocardial infarction.
MedLine Citation:
PMID:  3656605     Owner:  NLM     Status:  MEDLINE    
Two patients developed the cholesterol embolization syndrome after coronary angiography and intravenous streptokinase therapy for acute myocardial infarction. Clinical manifestations included cyanosis, ulcers, gangrene of the hands and feet, myalgias, intestinal infarction, eosinophilia, and renal failure. One patient died; one has survived with chronic renal failure. Streptokinase therapy may expose atheromatous plaques to the circulation by lysing platelet-fibrin thrombi.
M W Schwartz; G B McDonald
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  258     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-10-29     Completed Date:  1987-10-29     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1934-5     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Angiography*
Embolism, Fat / etiology*
Middle Aged
Myocardial Infarction / drug therapy
Streptokinase / adverse effects*,  therapeutic use
Reg. No./Substance:
97C5T2UQ7J/Cholesterol; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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