Document Detail


Cholesterol crystallite nucleation in supersaturated model biles from a thermodynamic standpoint.
MedLine Citation:
PMID:  12379309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A rapid, silicone polymer film uptake method was used to determine the cholesterol (Ch) thermodynamic activity (A(T)) in taurocholate (TC)-lecithin (L) and taurochenodeoxycholate (TCDC)-L model biles supersaturated with Ch. Also, time-dependent quasielastic light scattering (QLS) measurements and microscopic observations were made to determine the nature of particle species and the Ch nucleation times. In all cases in which Ch-L vesicles were present, a linear relationship between the logarithm of Ch nucleation times and Ch A(T) was found. These findings support that Ch A(T) is the appropriate parameter that represents the Ch nucleation tendency and that vesicles are catalytic sites in the Ch nucleation process. When Ca2+, a nucleation promoter ion, was present in the supersaturated model biles, the increased values of Ch A(T) quantitatively correlated with shorter Ch nucleation times. These latter findings further demonstrate that Ch A(T) is the dominant factor in explaining the Ch nucleation tendencies in supersaturated model biles.
Authors:
Chen-Lun Liu; William I Higuchi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1588     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-15     Completed Date:  2002-12-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  15-25     Citation Subset:  IM    
Affiliation:
Institute of Biotechnology, National Dong-Hwa University, Shou-Feng, Hualien Hsien 974, Taiwan, ROC. cliu@mail.ndhu.edu.tw
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MeSH Terms
Descriptor/Qualifier:
Bile / chemistry*
Calcium
Catalysis
Cations, Divalent
Chemical Precipitation
Cholesterol / chemistry*
Crystallization
Models, Theoretical
Phosphatidylcholines / chemistry
Solutions*
Taurochenodeoxycholic Acid / chemistry
Taurocholic Acid / chemistry
Thermodynamics
Time Factors
Grant Support
ID/Acronym/Agency:
DK 32472/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cations, Divalent; 0/Phosphatidylcholines; 0/Solutions; 516-35-8/Taurochenodeoxycholic Acid; 57-88-5/Cholesterol; 7440-70-2/Calcium; 81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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