| Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer. | |
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MedLine Citation:
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PMID: 8293385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The authors have previously demonstrated in different experimental models that sustained processes of cellular growth are characterized by alterations of cholesterol metabolism not only in the proliferating tissues but also in the plasma compartment. METHODS: To evaluate whether alterations of cholesterol metabolism similar to those observed in experimental models are also associated with human cancer, in the present study cholesterol distribution in tumor tissues and lipid composition in the plasma compartment were determined in patients with different types of gastrointestinal cancer. RESULTS: The results showed that tumor tissues contain increased amounts of cholesterol when compared with the corresponding normal tissues. Intracellular alterations of cholesterol were accompanied by specific changes of cholesterol in the plasma compartment: high-density lipoprotein (HDL) cholesterol was markedly reduced in the serum of patients with gastrointestinal cancer and the lipoprotein profiles showed a decrease in HDL3 fraction, the main HDL subfraction in human serum. The decrease of HDL cholesterol was negatively associated with the clinical stage of the disease. No changes in either total or low-density lipoprotein cholesterol levels were observed. CONCLUSIONS: A major function attributed to HDL is to maintain normal cell cholesterol homeostasis by removing excess of cholesterol from intracellular pools. Because the use and storage of cholesterol are increased within the tumor tissues during growth, it is possible to hypothesize that low HDL levels observed in patients with gastrointestinal cancer are associated with the increased cholesterol metabolism in proliferating tissues. |
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Authors:
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S Dess?; B Batetta; D Pulisci; O Spano; C Anchisi; L Tessitore; P Costelli; F M Baccino; E Aroasio; P Pani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 73 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-02-25 Completed Date: 1994-02-25 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-8 Citation Subset: AIM; IM |
Affiliation:
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Istituto di Patologia Sperimentale, Cagliari, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cholesterol / blood, metabolism* Cholesterol, HDL / blood* Cholesterol, LDL / blood Gastrointestinal Neoplasms / blood, metabolism*, pathology Homeostasis Humans Middle Aged Neoplasm Staging Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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