Document Detail


Cholesterol, the central lipid of mammalian cells.
MedLine Citation:
PMID:  20627678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite its importance for mammalian cell biology and human health, there are many basic aspects of cholesterol homeostasis that are not well understood. Even for the well-characterized delivery of cholesterol to cells via lipoproteins, a novel regulatory mechanism has been discovered recently, involving a serum protein called PCSK9, which profoundly affects lipoproteins and their receptors. Cells can export cholesterol by processes that require the activity of ABC transporters, but the molecular mechanisms for cholesterol transport remain unclear. Cholesterol levels in different organelles vary by 5-10-fold, and the mechanisms for maintaining these differences are now partially understood. Several proteins have been proposed to play a role in the inter-organelle movement of cholesterol, but many aspects of the mechanisms for regulating intracellular transport and distribution of cholesterol remain to be worked out. The endoplasmic reticulum is the main organelle responsible for regulation of cholesterol synthesis, and careful measurements have shown that the proteins responsible for sterol sensing respond over a very narrow range of cholesterol concentrations to provide very precise, switch-like control over cholesterol synthesis.
Authors:
Frederick R Maxfield; Gerrit van Meer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-06-02
Journal Detail:
Title:  Current opinion in cell biology     Volume:  22     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-10-28     Revised Date:  2014-01-07    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  422-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism
Cells / metabolism*
Cholesterol / metabolism*
Homeostasis
Humans
Mammals / metabolism*
Grant Support
ID/Acronym/Agency:
R37 DK027083/DK/NIDDK NIH HHS; R37 DK027083-32/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
97C5T2UQ7J/Cholesterol
Comments/Corrections

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