Document Detail


Cholesterol and carotid artery wall in children and adolescents with familial hypercholesterolaemia: a controlled study by ultrasound.
MedLine Citation:
PMID:  9401514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The carotid artery wall was studied with ultrasound in 23 children and adolescents with familial hypercholesterolaemia and in 23 age-matched healthy controls. The study revealed changes in the carotid artery wall related both to familial hypercholesterolaemia and to age. In the control subjects, the carotid artery wall became stiffer with age. In the patients with hypercholesterolaemia, no clear age-dependence was found, but wall stiffness correlated with total and low-density lipoprotein cholesterol. The intimal-medial wall thickness was associated with serum total cholesterol, low-density lipoprotein and triglyceride concentrations, and correlated inversely with the ratio of high-density lipoprotein to total cholesterol. Carotid artery wall properties seem to be associated with the degree of hypercholesterolaemia and the high-density lipoprotein-to-total cholesterol ratio even in children. In childhood and adolescence it is already possible, with ultrasound, to detect changes in the arterial wall related both to familial hypercholesterolaemia and to age.
Authors:
K Virkola; E Pesonen; H K Akerblom; M A Siimes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  86     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-13     Completed Date:  1998-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1203-7     Citation Subset:  IM    
Affiliation:
Department of Radiology, Helsinki University Central Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aging / pathology
Blood Pressure
Carotid Arteries / pathology,  ultrasonography*
Child
Child, Preschool
Female
Humans
Hyperlipoproteinemia Type II / blood,  pathology,  ultrasonography*
Lipids / blood
Male
Reference Values
Chemical
Reg. No./Substance:
0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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