| Cholesterol and cardiac arrhythmias. | |
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MedLine Citation:
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PMID: 20602558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac arrhythmias are a leading cause of morbidity and mortality in the Western world. Ventricular arrhythmias are reportedly responsible for the majority of sudden cardiac deaths and atrial fibrillation is responsible for 15% of all strokes in the USA. Recent evidence suggests a role for cholesterol in the development of these arrhythmias. In addition to its association with atherosclerotic plaques, high cholesterol has been shown to cause changes in membrane properties, including the function of hormone receptors, ion channels and pumps. These effects are mediated through direct interactions between cholesterol and the membrane proteins, through changes in membrane fluidity and/or an association with lipid rafts. Cholesterol-lowering therapy, therefore, may prove an effective method for the treatment of cardiac arrhythmias. Statins, a class of cholesterol-lowering drugs, have been frequently shown to protect against ventricular arrhythmias and atrial fibrillation. Some of this protection may stem from their cholesterol-lowering activities. |
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Authors:
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Charitha L Goonasekara; Elise Balse; Stephan Hatem; David F Steele; David Fedida |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 8 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-06 Completed Date: 2010-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 965-79 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / therapeutic use Arrhythmias, Cardiac / drug therapy, etiology*, prevention & control Atrial Fibrillation / prevention & control Cell Membrane / physiology Cholesterol / biosynthesis, blood*, metabolism Heart Ventricles Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Ion Channels / metabolism Ion Pumps / metabolism Membrane Fluidity Membrane Microdomains / physiology Myocardium / metabolism Protein Transport Receptors, Cell Surface / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Ion Channels; 0/Ion Pumps; 0/Receptors, Cell Surface; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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