Document Detail

Cholesterol and bile acid metabolism in obesity.
MedLine Citation:
PMID:  7428289     Owner:  NLM     Status:  MEDLINE    
1. The present study was undertaken to determine the influence of obesity on bile acid kinetics and cholesterol balance in man. 2. Fourteen obese and normolipidaemic patients (160 +/- 6% of ideal body weight, mean +/- SEM) were studied under standardized dietary conditions. Bile acid kinetics, were determined with the aid of 14C-labelled cholic acid and chenodeoxycholic acid. Cholesterol balance was calculated as the sum of bile acid synthesis plus daily faecal excretion of neutral C27 steroids minus dietary intake of cholesterol. The results obtained were compared with previously published data on control subjects (n = 13). 3. The cholesterol balance was higher in the obese patients (2.61 +/- 0.27 mmol/day) than in the control subjects (1.78 +/- 0.22 mmol/day), owing to a higher excretion of neutral steroids. When expressed per kg of body weight the cholesterol balance was quite normal in the obese patients.
B Leijd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  59     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-01-16     Completed Date:  1981-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
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MeSH Terms
Chenodeoxycholic Acid / metabolism*
Cholesterol / metabolism*
Cholic Acids / metabolism*
Middle Aged
Obesity / metabolism*
Steroids / metabolism
Reg. No./Substance:
0/Cholic Acids; 0/Steroids; 474-25-9/Chenodeoxycholic Acid; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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