Document Detail

Cholesterol absorption: influence of body weight and the role of plant sterols.
MedLine Citation:
PMID:  16256005     Owner:  NLM     Status:  MEDLINE    
Cholesterol absorption and synthesis are inter-regulated, so if one changes then the other changes in the opposite direction. The regulation and detailed mechanism of cholesterol absorption have been intensely investigated. Inhibition of cholesterol absorption has become an additional factor for cholesterol lowering. Agents inhibiting cholesterol absorption, mainly plant stanols and sterols or ezetimibe, usually lower low-density lipoprotein cholesterol in monotherapy by less than 20%, indicating that these inhibitors can normalize cholesterol levels only in patients with a modest baseline hypercholesterolemia. Body weight, especially obesity with and without diabetes, and dietary plant sterols alter cholesterol absorption differently. This article briefly reviews some special questions of cholesterol absorption under these conditions.
Helena Gylling; Tatu A Miettinen
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  7     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-31     Completed Date:  2006-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-71     Citation Subset:  IM    
Division of Internal Medicine, Department of Medicine, University of Helsinki, Biomedicum Helsinki, PO Box 700, FIN-00029, Helsinki, Finland.
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MeSH Terms
Absorption / drug effects
Body Mass Index
Body Weight*
Cholesterol / blood,  metabolism*
Cholesterol, HDL / drug effects,  metabolism
Cholesterol, LDL / drug effects,  metabolism
Phytosterols / metabolism,  therapeutic use*
Sensitivity and Specificity
Treatment Outcome
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Phytosterols; 57-88-5/Cholesterol

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