Document Detail


Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain.
MedLine Citation:
PMID:  19489738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cholesterol 24-hydroxylase is a highly conserved cytochrome P450 that is responsible for the majority of cholesterol turnover in the vertebrate central nervous system. The enzyme is expressed in neurons, including hippocampal and cortical neurons that are important for learning and memory formation. Disruption of the cholesterol 24-hydroxylase gene in the mouse reduces both cholesterol turnover and synthesis in the brain but does not alter steady-state levels of cholesterol in the tissue. The decline in synthesis reduces the flow of metabolites through the cholesterol biosynthetic pathway, of which one, geranylgeraniol diphosphate, is required for learning in the whole animal and for synaptic plasticity in vitro. This review focuses on how the link between cholesterol metabolism and higher-order brain function was experimentally established.
Authors:
David W Russell; Rebekkah W Halford; Denise M O Ramirez; Rahul Shah; Tiina Kotti
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of biochemistry     Volume:  78     ISSN:  1545-4509     ISO Abbreviation:  Annu. Rev. Biochem.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-07-23     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  2985150R     Medline TA:  Annu Rev Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1017-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology,  metabolism*
Cholesterol / metabolism*
Gene Expression Regulation, Enzymologic
Hippocampus / metabolism
Humans
Learning
Neurons / metabolism
Steroid Hydroxylases / chemistry,  genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
DK 81182/DK/NIDDK NIH HHS; GM 69338/GM/NIGMS NIH HHS; HL 20948/HL/NHLBI NIH HHS; P01 HL020948/HL/NHLBI NIH HHS; P01 HL020948-259003/HL/NHLBI NIH HHS; PL1 DK081182/DK/NIDDK NIH HHS; PL1 DK081182-02/DK/NIDDK NIH HHS; PL1 DK081182-02S1/DK/NIDDK NIH HHS; U54 GM069338/GM/NIGMS NIH HHS; U54 GM069338-019008/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
97C5T2UQ7J/Cholesterol; EC 1.14.-/Steroid Hydroxylases; EC 1.14.-/cholesterol 24-hydroxylase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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