Document Detail

Cholestatic liver disease overlap syndromes.
MedLine Citation:
PMID:  23540500     Owner:  NLM     Status:  In-Data-Review    
Primary biliary cirrhosis and primary sclerosing cholangitis share some clinical features with autoimmune hepatitis, but when features of autoimmune hepatitis are present, prognosis can be affected and immunosuppressive treatment warranted. The presence of severe interface hepatitis in primary biliary cirrhosis portends a worse prognosis and should prompt evaluation for possible autoimmune hepatitis overlap and treatment with immunosuppression. Specific models to identify which subjects benefit most from the addition of immunosuppression need to be developed. Drug-induced liver injury and IgG4 disease may masquerade as autoimmune hepatitis or primary sclerosing cholangitis and are important to consider in the differential diagnosis of the overlap or variant syndromes.
Marlyn J Mayo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in liver disease     Volume:  17     ISSN:  1557-8224     ISO Abbreviation:  Clin Liver Dis     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-9151, USA. Electronic address:
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