| Cholestasis of pregnancy. Clinical and laboratory studies. | |
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MedLine Citation:
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PMID: 3727939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective study was made of clinical symptoms, liver function and pregnancy prognosis in women with cholestasis of pregnancy (CP). We used several positive and negative criteria to allow a clinical definition of CP as itching limited to time of pregnancy with or without laboratory evidence of liver dysfunction. The incidence during 1971-74 was 1.5% (100/6798 women) and lower during 1980-82 (52/5441 = 1.0%). One hundred consecutive pregnant women without itching were used as clinical controls. The incidence of CP showed a distinct seasonal variation, culminating in November. Women with CP had often had itching during previous pregnancies and during use of contraceptive pills and described anamnestically itching in mother and sisters. Laboratory data in CP were compared with reference intervals for healthy pregnant women. Serum enzyme levels were significantly increased for serum alkaline phosphatase, 5-nucleotidase, aspartate aminotransferase and alanine aminotransferase in the second and especially in the third trimester. The enzyme distribution was often markedly skewed to the right, i.e. some patients reacted more than others. Most patients with cholestasis only had itching without pronounced abnormalities in laboratory data. This mild form of CP was associated with a good prognosis for both mother and child. |
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Authors:
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B Berg; G Helm; L Petersohn; N Tryding |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 65 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 1986 |
Date Detail:
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Created Date: 1986-08-19 Completed Date: 1986-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 107-13 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholestasis / diagnosis*, enzymology, epidemiology Female Fetal Death / etiology Humans Infant Mortality Infant, Newborn Liver Function Tests Pregnancy Pregnancy Complications / diagnosis*, enzymology, epidemiology Prognosis Prospective Studies Seasons Sweden |
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