| Cholestasis of pregnancy. | |
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MedLine Citation:
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PMID: 20685553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrahepatic cholestasis (ICP) of pregnancy is a disease that is likely multifactorial in etiology and has a prevalence that varies by geography and ethnicity. The diagnosis is made when patients have a combination of pruritus and abnormal liver-function tests. It is associated with a high risk for adverse perinatal outcome, including preterm birth, meconium passage, and fetal death. As of yet, the cause for fetal death is unknown. Because fetal deaths caused by ICP appear to occur predominantly after 37 weeks, it is suggested to offer delivery at approximately 37 weeks. Ursodeoxycholic acid appears to be the most effective medication to improve maternal pruritus and liver-function tests; however, there is no medication to date that has been shown to reduce the risk for fetal death. |
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Authors:
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Bhuvan Pathak; Lili Sheibani; Richard H Lee |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Obstetrics and gynecology clinics of North America Volume: 37 ISSN: 1558-0474 ISO Abbreviation: Obstet. Gynecol. Clin. North Am. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-12-06 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 8709551 Medline TA: Obstet Gynecol Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 269-82 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Southern California, 2020 Zonal Avenue, IRD, Room 203, Los Angeles, CA 90033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholestasis, Intrahepatic*
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diagnosis,
drug therapy,
genetics Delivery, Obstetric Female Fetal Diseases / epidemiology Gestational Age Humans Pregnancy Pregnancy Complications* / diagnosis, drug therapy, genetics Pregnancy Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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