Document Detail

Cholestasis of pregnancy.
MedLine Citation:
PMID:  20685553     Owner:  NLM     Status:  MEDLINE    
Intrahepatic cholestasis (ICP) of pregnancy is a disease that is likely multifactorial in etiology and has a prevalence that varies by geography and ethnicity. The diagnosis is made when patients have a combination of pruritus and abnormal liver-function tests. It is associated with a high risk for adverse perinatal outcome, including preterm birth, meconium passage, and fetal death. As of yet, the cause for fetal death is unknown. Because fetal deaths caused by ICP appear to occur predominantly after 37 weeks, it is suggested to offer delivery at approximately 37 weeks. Ursodeoxycholic acid appears to be the most effective medication to improve maternal pruritus and liver-function tests; however, there is no medication to date that has been shown to reduce the risk for fetal death.
Bhuvan Pathak; Lili Sheibani; Richard H Lee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology clinics of North America     Volume:  37     ISSN:  1558-0474     ISO Abbreviation:  Obstet. Gynecol. Clin. North Am.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-12-06     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  8709551     Medline TA:  Obstet Gynecol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-82     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Southern California, 2020 Zonal Avenue, IRD, Room 203, Los Angeles, CA 90033, USA.
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MeSH Terms
Cholestasis, Intrahepatic* / diagnosis,  drug therapy,  genetics
Delivery, Obstetric
Fetal Diseases / epidemiology
Gestational Age
Pregnancy Complications* / diagnosis,  drug therapy,  genetics
Pregnancy Outcome

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