Document Detail

Cholera toxin differentially regulates nitric oxide synthesis, tumor necrosis factor-alpha production and respiratory burst in murine macrophages.
MedLine Citation:
PMID:  9848679     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine if cholera toxin can modulate the expression of several macrophage effector functions. The effect of cholera toxin on the induction of NO synthesis, production of tumor necrosis factor-alpha and induction of respiratory burst was examined in the J774.A2 macrophage cell line. Pre-incubation of cell cultures with cholera toxin significantly down-regulated lipopolysaccharide-induced NO synthesis and phorbol-12-myristate-13-acetate-induced respiratory burst. Concomitant addition of cholera toxin and lipopolysaccharide to cell cultures enhanced the production of tumor necrosis factor-alpha. These effects were abrogated when cholera toxin was inactivated by heat or treated with a specific monoclonal antibody.
B L Rodríguez; A Rojas; J A Benítez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  22     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Departamento de Genética, Centro Nacional de Investigaciones Científicas, Havana, Cuba.
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MeSH Terms
Cholera Toxin / pharmacology*
Lipopolysaccharides / pharmacology*
Macrophages / metabolism*
Nitric Oxide / biosynthesis*
Nitrites / metabolism
Respiratory Burst / drug effects*
Tetradecanoylphorbol Acetate / pharmacology
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha / biosynthesis*
Vibrio cholerae*
Reg. No./Substance:
0/Lipopolysaccharides; 0/Nitrites; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide; 16561-29-8/Tetradecanoylphorbol Acetate; 9012-63-9/Cholera Toxin

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