| Choledochoscope manometry about different drugs on the Sphincter of Oddi. | |
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MedLine Citation:
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PMID: 18855992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the effects of H(2)-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents on the human Sphincter of Oddi (SO) motility by choledochoscope manometry. METHODS: One hundred and seventy-five patients with T tube installed after cholecystectomy and choledochotomy were assessed by choledochoscope manometry. They were randomly assigned into groups of H(2)-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents. The Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duodenal pressure (DP), and common bile duct pressure (CBDP) were scored and analyzed. RESULTS: SOBP and SOCA were significantly decreased after cimetidine administration, and no statistical difference was seen in the famotidine group. In the gabexate mesilate group, SOBP had decreased significantly. In the ulinastatin group, SOCA decreased when ulinastatin was given at the rate of 2500 U/min; when ulinastatin administration was raised to 5000 U/min, SOBP, SOF and SOCA all experienced a fall. SOBP and SOCA for domperidone and SOCA for mosapride groups all decreased distinctly after administration. CONCLUSION: The regular dosage of cimetidine showed an inhibitory effect on the motility of SO, while famotidine had no obvious effects otherwise. Gabnexata mesilate, ulinastatin and gastro kinetic agents also showed inhibitory effects on the SO motility. |
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Authors:
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Jing Kong; Shuo-Dong Wu; Xiao-Bo Zhang; Zhen-Sheng Li; Gang Shi; Wei Wang; Jun-Zhi Chen |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 14 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-04-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5907-12 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Benzamides / therapeutic use Cholecystectomy Cimetidine / therapeutic use Domperidone / therapeutic use Endoscopes* Famotidine / therapeutic use Female Gabexate / therapeutic use Gastrointestinal Agents / therapeutic use* Glycoproteins / therapeutic use Histamine H2 Antagonists / therapeutic use* Humans Male Manometry / instrumentation* Middle Aged Morpholines / therapeutic use Muscle Contraction / drug effects Pressure Serine Proteinase Inhibitors / therapeutic use* Sphincter of Oddi / drug effects*, physiopathology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/Gastrointestinal Agents; 0/Glycoproteins; 0/Histamine H2 Antagonists; 0/Morpholines; 0/Serine Proteinase Inhibitors; 112885-42-4/mosapride; 39492-01-8/Gabexate; 51481-61-9/Cimetidine; 57808-66-9/Domperidone; 76824-35-6/Famotidine; 80449-32-7/urinastatin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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