Document Detail


CholecystokininB receptor antagonist increases food intake in rats.
MedLine Citation:
PMID:  9811359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the role of cholecystokininB (CCKB) receptors in the brain in the control of food intake, we administered PD-135158, a specific and potent CCKB antagonist, into the lateral ventricle of male, Sprague-Dawley rats 30 min before a 60-min intake test. PD-135158 (0.001-0.5 mg) increased intake significantly; the mean peak increase was 39% more than the intake after vehicle treatment. The increased intake was due to a larger first meal and more intake during the last 30 min of the test. Because intake during the first 3 min, a measure of palatability or orosensory stimulation did not change significantly, we suggest that antagonism of brain CCK at central CCKB receptors decreased the satiating potency of the ingested food during the meal and decreased the potency of the mechanisms that prevent the reinitiation of eating during the postprandial intermeal interval.
Authors:
D Dorré; G P Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  65     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-01-29     Completed Date:  1999-01-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Cornell University Medical College, New York Hospital-Cornell Medical Center, White Plains 10605, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Anxiety Agents / pharmacology*
Benzodiazepinones / pharmacology*
Brain Chemistry / drug effects
Dose-Response Relationship, Drug
Eating / drug effects*
Indoles / pharmacology*
Injections, Intraventricular
Male
Meglumine / analogs & derivatives*,  pharmacology
Phenylurea Compounds / pharmacology*
Rats
Rats, Sprague-Dawley
Receptor, Cholecystokinin B
Receptors, Cholecystokinin / antagonists & inhibitors*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
MH00149/MH/NIMH NIH HHS; MH40010/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Benzodiazepinones; 0/Indoles; 0/Phenylurea Compounds; 0/Receptor, Cholecystokinin B; 0/Receptors, Cholecystokinin; 118101-09-0/L 365260; 130325-35-8/PD 135158; 6284-40-8/Meglumine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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