| Cholecystokinin and stomach distension combine to reduce food intake in humans. | |
| | |
MedLine Citation:
|
PMID: 12920059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to test the hypothesis that gastric distension can enhance the effect of cholecystokinin (CCK) on reduction of food intake in men and women. Eight normal-weight subjects of each gender were tested four times each with either CCK or saline infusion crossed with gastric distension or no distension. Intravenous infusion of a low dose of CCK octapeptide (CCK-8; 112 ng/min for 23 min) combined with a subthreshold gastric distension induced by a water-filled balloon (300 ml) resulted in a significant (means +/- SED: 191 +/- 61 g in men, 209 +/- 61 g in women, and 200 +/- 43 g combined) reduction in intake of a liquid meal compared with saline infusion and unfilled gastric balloon. This combined effect was the result of a large and significant CCK effect when the stomach was distended (CCK vs. saline with distension: 169 +/- 43 g) and a small and insignificant distension effect (distension vs. no distension without CCK: 31 +/- 43 g). The CCK effect alone on intake (CCK vs. saline) without distension was not significant in men (72 +/- 61 g) but was significant in women (121 +/- 61 g). These results are consistent with the hypothesis that CCK's suppression of food intake is enhanced when the stomach is distended. |
| | |
Authors:
|
Harry R Kissileff; Julie C Carretta; Allan Geliebter; F Xavier Pi-Sunyer |
Related Documents
:
|
6093149 - Changes in brain monoamine levels of rats during cholecystokinin octapeptide-induced su... 15130879 - Amylin receptor blockade stimulates food intake in rats. 22613899 - Cellulose solvent- and organic solvent-based lignocellulose fractionation enabled effic... 12887419 - The effect of urocortin on ingestive behaviours and brain fos immunoreactivity in mice. 22379689 - International conference on harmonisation; final recommendation for the revision of the... 17135729 - Effects of a preload on reduction of food intake by glp-1 in healthy subjects. 15936029 - Factors that influence freezing in the sub-antarctic springtail tullbergia antarctica. 17367789 - Photorefractoriness in birds--photoperiodic and non-photoperiodic control. 12604969 - Complementary food supplements to achieve micronutrient adequacy for infants and young ... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-08-14 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 285 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-10-14 Completed Date: 2003-11-21 Revised Date: 2012-07-02 |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R992-8 Citation Subset: IM |
Affiliation:
|
St. Luke's/Roosevelt Hospital, 1111 Amsterdam Ave., New York, NY 10025, USA. hrk2@columbia.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Appetite Depressants / administration & dosage* Balloon Dilation Eating / drug effects*, physiology Female Gastric Dilatation Gastric Emptying / physiology Humans Male Obesity / drug therapy*, physiopathology Sex Factors Sincalide / administration & dosage* Stomach / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
DK-26687/DK/NIDDK NIH HHS; DK-36507/DK/NIDDK NIH HHS; DK-53089/DK/NIDDK NIH HHS; R01 DK054318/DK/NIDDK NIH HHS; R01 DK054318-01A1/DK/NIDDK NIH HHS; R01 DK054318-02/DK/NIDDK NIH HHS; R01 DK054318-03/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Appetite Depressants; 25126-32-3/Sincalide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A two-barrier compartment model for volume flow across amphibian skin.
Next Document: Sympathetic activity and the underlying action potentials in sympathetic nerves: a simulation.