Document Detail


Cholecystokinin and stomach distension combine to reduce food intake in humans.
MedLine Citation:
PMID:  12920059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to test the hypothesis that gastric distension can enhance the effect of cholecystokinin (CCK) on reduction of food intake in men and women. Eight normal-weight subjects of each gender were tested four times each with either CCK or saline infusion crossed with gastric distension or no distension. Intravenous infusion of a low dose of CCK octapeptide (CCK-8; 112 ng/min for 23 min) combined with a subthreshold gastric distension induced by a water-filled balloon (300 ml) resulted in a significant (means +/- SED: 191 +/- 61 g in men, 209 +/- 61 g in women, and 200 +/- 43 g combined) reduction in intake of a liquid meal compared with saline infusion and unfilled gastric balloon. This combined effect was the result of a large and significant CCK effect when the stomach was distended (CCK vs. saline with distension: 169 +/- 43 g) and a small and insignificant distension effect (distension vs. no distension without CCK: 31 +/- 43 g). The CCK effect alone on intake (CCK vs. saline) without distension was not significant in men (72 +/- 61 g) but was significant in women (121 +/- 61 g). These results are consistent with the hypothesis that CCK's suppression of food intake is enhanced when the stomach is distended.
Authors:
Harry R Kissileff; Julie C Carretta; Allan Geliebter; F Xavier Pi-Sunyer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-08-14
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  285     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-14     Completed Date:  2003-11-21     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R992-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Appetite Depressants / administration & dosage*
Catheterization
Eating / drug effects*,  physiology
Female
Gastric Dilatation
Gastric Emptying / physiology
Humans
Male
Obesity / drug therapy*,  physiopathology
Sex Factors
Sincalide / administration & dosage*
Stomach / physiology*
Grant Support
ID/Acronym/Agency:
DK-26687/DK/NIDDK NIH HHS; DK-36507/DK/NIDDK NIH HHS; DK-53089/DK/NIDDK NIH HHS; R01 DK054318/DK/NIDDK NIH HHS; R01 DK054318-01A1/DK/NIDDK NIH HHS; R01 DK054318-02/DK/NIDDK NIH HHS; R01 DK054318-03/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Appetite Depressants; M03GIQ7Z6P/Sincalide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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