| Cholecystokinin and satiety in rats and rhesus monkeys. | |
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MedLine Citation:
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PMID: 404865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When ingested food does not accumulate in the stomach or enter the small intestine, rats do not stop eating. Small amounts of food placed in the small intestine or intraperitoneal injections of the intestinal hormone cholecystokinin (CCK) elicit the full behavioral display of satiety in these sham-feeding rats. In rhesus monkeys, intravenous infusions of CCK produce large, dose-related reductions in meal size. In addition, gastric preloads of calorically trivial amounts of l-phenylalanine, but not d-phenylalanine, produce large reductions in meal size, suggesting that: 1) endogenous CCK acts as a "satiety signal," and 2) certain foods may be very efficient releasers of such a satiety signal. Whether the satiety effect of CCK is physiological in rats and monkeys or operates in humans has not been determined. |
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Authors:
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J Gibbs; G P Smith |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 30 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-06-22 Completed Date: 1977-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 758-61 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation / drug effects Cholecystokinin / pharmacology*, physiology Diet* Haplorhini Intubation, Gastrointestinal Macaca mulatta Phenylalanine / pharmacology Rats Satiation / drug effects* Species Specificity Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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63-91-2/Phenylalanine; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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