Document Detail


Cholecystokinin and satiety in rats and rhesus monkeys.
MedLine Citation:
PMID:  404865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When ingested food does not accumulate in the stomach or enter the small intestine, rats do not stop eating. Small amounts of food placed in the small intestine or intraperitoneal injections of the intestinal hormone cholecystokinin (CCK) elicit the full behavioral display of satiety in these sham-feeding rats. In rhesus monkeys, intravenous infusions of CCK produce large, dose-related reductions in meal size. In addition, gastric preloads of calorically trivial amounts of l-phenylalanine, but not d-phenylalanine, produce large reductions in meal size, suggesting that: 1) endogenous CCK acts as a "satiety signal," and 2) certain foods may be very efficient releasers of such a satiety signal. Whether the satiety effect of CCK is physiological in rats and monkeys or operates in humans has not been determined.
Authors:
J Gibbs; G P Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  30     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  758-61     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / drug effects
Cholecystokinin / pharmacology*,  physiology
Diet*
Haplorhini
Intubation, Gastrointestinal
Macaca mulatta
Phenylalanine / pharmacology
Rats
Satiation / drug effects*
Species Specificity
Stereoisomerism
Chemical
Reg. No./Substance:
63-91-2/Phenylalanine; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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