Document Detail

Cholecystokinin: proofs and prospects for involvement in control of food intake and body weight.
MedLine Citation:
PMID:  10657516     Owner:  NLM     Status:  MEDLINE    
Evidence that CCK participates in the control of meal size is compelling, but the avenues by which CCK may affect daily food intake and body weight regulation are still uncertain. Although participation of brain CCK in control of food intake is acknowledged, our focus here is on participation of peripheral CCK in the control of food intake. Therefore, in this article we (1) review evidence for CCK's participation in control of meal size, (2) document involvement of CCK-A receptors located on vagal sensory neurons in control of food intake by exogenous and endogenous CCK, (3) point out apparent discrepancies in the experimental record, which auger for non-endocrine sources of CCK and non-vagal sites of CCK action, and (4) summarize recent observations, suggesting mechanisms by which CCK could participate in the control of daily food intake and body weight regulation.
R C Ritter; M Covasa; C A Matson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Neuropeptides     Volume:  33     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-06-02     Completed Date:  2000-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  387-99     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Harcourt Publishers Ltd.
Department of VCAPP and Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
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MeSH Terms
Body Weight / physiology*
Cholecystokinin / physiology*
Eating / physiology*
Grant Support
R01 20561//PHS HHS
Reg. No./Substance:

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