| Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. | |
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MedLine Citation:
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PMID: 6326618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Food and water intake of free-feeding rats with indwelling intraperitoneal catheters connected to infusion pumps was continuously monitored and recorded by a microcomputer-based data acquisition system. Initially, at the start of every spontaneous meal for 4 days, each rat was infused with 0.27 ml of physiological saline. Saline infusion did not affect any feeding or drinking patterns, and the rate of weight gain remained unchanged. For 6 subsequent days, the octapeptide of cholecystokinin (CCK-8, 1.1 micrograms/meal) dissolved in physiological saline was infused at the onset of each meal. CCK-8 infusion caused a dramatic shift of patterns of food intake. Average meal size was reduced by at least 44%, whereas daily meal number increased by 162% or more for all 6 days of CCK-8 infusion. Total daily food intake recovered to predrug levels by the 4th day of CCK-8 infusion, primarily due to increased feeding frequency. Average body weight dropped by 12.4 g on the 1st day of CCK infusion, but over the following 5 days the growth rate was not different from the base-line predrug rate. With discontinuation of CCK-8 infusion all meal patterns returned rapidly to normal and body weight immediately recovered. |
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Authors:
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D B West; D Fey; S C Woods |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 246 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-06-20 Completed Date: 1984-06-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R776-87 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Drinking / drug effects Drinking Behavior / drug effects Eating / drug effects* Feeding Behavior / drug effects* Male Rats Rats, Inbred Strains Sincalide / pharmacology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AM-17844/AM/NIADDK NIH HHS; GM-07108-08/GM/NIGMS NIH HHS; RR-07096/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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25126-32-3/Sincalide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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