| Cholecystokinin and peptide YY are released by fat in either proximal or distal small intestine in dogs. | |
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MedLine Citation:
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PMID: 12832101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We tested the hypothesis that the release of cholecystokinin (CCK) and peptide YY (PYY) may be independent of the region of the small intestine exposed to fat. In five dogs equipped with duodenal and midgut fistulas, the small intestine was compartmentalized so that fat was confined to either the proximal or distal one-half of the gut. Plasma CCK and PYY levels were measured by radioimmunoassay and compared by the square root of the area under the curve (sqrt AUC), representing the plasma peptide concentration over time. CCK was released similarly whether fat was delivered into the proximal (69.9+/-4.7 pM) or distal (71.0+/-5.5 pM) gut, but significantly more CCK (88.9+/-5.6 pM; p<0.05) was released when both the proximal and distal gut were perfused simultaneously with fat. PYY was released similarly whether fat was delivered into the proximal (34.9+/-2.6 pM) or distal (40.0+/-1.2 pM) gut or both (38.6+/-2.2 pM). We conclude that CCK and PYY are released by fat in either the proximal or distal one-half of the small intestine. |
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Authors:
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Henry C Lin; William Y Chey |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Regulatory peptides Volume: 114 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-30 Completed Date: 2004-04-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 131-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Cedars-Sinai Medical Center, Burns and Allen Research Institute, 8635 W. 3rd Street, #770 W, Los Angeles, CA 90048, USA. henry.lin@cshs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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secretion* Animals Cholecystokinin / blood, secretion* Dogs Intestine, Small / secretion* Peptide YY / blood, secretion* Radioimmunoassay |
| Grant Support | |
ID/Acronym/Agency:
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DDK 25692/DK/NIDDK NIH HHS; DK46459/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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106388-42-5/Peptide YY; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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