Document Detail

Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding.
MedLine Citation:
PMID:  504989     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin octapeptide decreased food intake in a dose-related manner when injected continuously into the lateral cerebral ventricles of sheep that had been deprived of food for 2, 4, 8, or 24 hours. In sheep deprived of food for 2 hours, as little as 0.01 picomole per minute suppressed feeding 35 percent 1 hour after beginning injection. Pentagastrin also decreased feeding in the 2-hour group, but only at a much higher dose range. Secretin had no effect. These findings support the hypothesis that cholecystokinin octapeptide acts on central nervous system structures that are involved in control of food intake.
M A Della-Fera; C A Baile
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  206     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-3     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects
Cholecystokinin / administration & dosage,  pharmacology*
Depression, Chemical
Feeding Behavior / drug effects*
Injections, Intraventricular
Pentagastrin / pharmacology
Peptide Fragments / pharmacology
Secretin / pharmacology
Species Specificity
Reg. No./Substance:
0/Peptide Fragments; 1393-25-5/Secretin; 5534-95-2/Pentagastrin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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