| Cholecystokinin mediation of colonic absorption via peptide YY: foregut-hindgut axis. | |
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MedLine Citation:
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PMID: 8661821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptide YY (PYY), a 36-amino-acid polypeptide, is found in abundance in the colon, a region where its physiologic roles are unknown. Previous studies have revealed a substantial increase in plasma PYY after cholecystokinin (CCK) administration. PYY is released from the hindgut in response to a meal and inhibits CCK release. In this study we evaluated the effects of CCK and PYY on intestinal absorption of water and electrolytes. Colonic, ileal, or jejunal Thiry-Vella fistulas (TVFs) were created in 12 dogs, and intestinal continuity was reestablished. The TVFs were perfused with an isotonic buffer solution containing [14C] PEG as a volume marker. Electrolyte and water transport were measured every 15 minutes, and plasma PYY and CCK levels were measured by radioimmunoassay. Group 1 dogs received an intravenous bolus of MK329, a specific CCK receptor antagonist, at 20 nmol/kg after a standard mixed meal; group 2 colonic TVF dogs received a meal and an intravenous bolus of PYY polyclonal antibody at 1 mg/kg. Postprandially, all three regions of the bowel became significantly proabsorptive for water, sodium, and chloride. In the colon postprandial absorption was abolished by MK329 starting 60 minutes after a meal, whereas specific CCK receptor blockade blunted ileal absorption. CCK receptor blockade did not affect postprandial absorption in the jejunum. Postprandial PYY levels did not rise in MK329-treated animals. PYY antibody reduced colonic absorption during the postprandial phase. Reduction of meal-induced colonic absorption and PYY release by MK329 in awake dogs suggests an important foregut-hindgut hormonal feedback loop. Foregut-derived CCK stimulates hindgut PYY release, which in turn stimulates colonic absorption while inhibiting further CCK release. |
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Authors:
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C D Liu; O J Hines; T R Newton; T E Adrian; M J Zinner; S W Ashley; D W McFadden |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: World journal of surgery Volume: 20 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 221-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzodiazepinones / pharmacology Buffers Carbon Radioisotopes / diagnostic use Chlorides / pharmacokinetics Cholecystokinin / analysis, blood, pharmacology* Colon / drug effects*, metabolism Devazepide Digestion Dogs Electrolytes / pharmacokinetics Feedback / drug effects Female Gastrointestinal Hormones / blood, pharmacology* Hormone Antagonists / pharmacology Ileum / drug effects, metabolism Intestinal Absorption / drug effects* Isotonic Solutions Jejunum / drug effects, metabolism Peptide YY Peptides / blood, pharmacology* Receptors, Cholecystokinin / analysis Sodium / pharmacokinetics Water / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK-39879/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzodiazepinones; 0/Buffers; 0/Carbon Radioisotopes; 0/Chlorides; 0/Electrolytes; 0/Gastrointestinal Hormones; 0/Hormone Antagonists; 0/Isotonic Solutions; 0/Peptides; 0/Receptors, Cholecystokinin; 103420-77-5/Devazepide; 106388-42-5/Peptide YY; 7440-23-5/Sodium; 7732-18-5/Water; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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