Document Detail

Cholecystokinin-like immunoreactivity occurs in ocular sensory neurons and partially co-localizes with substance P.
MedLine Citation:
PMID:  2428436     Owner:  NLM     Status:  MEDLINE    
Based on immunohistochemical analysis of the trigeminal, superior cervical, ciliary and sphenopalatine ganglia and of the eye after sensory denervation and sympathectomy, cholecystokinin (CCK)-like immunoreactive nerves in the guinea pig eye derive from the trigeminal ganglion. Substance P (SP) also occurs in some ocular sensory neurons, suggesting the possible co-localization in this system of CCK- and SP-immunoreactivities. A double-labeling immunofluorescence technique stained 3 types of trigeminal cells and ocular nerve fibers: some immunoreactive for both peptides, some immunoreactive only for CCK and some immunoreactive only for SP.
Y Kuwayama; R A Stone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  381     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-11-20     Completed Date:  1986-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  266-74     Citation Subset:  IM    
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MeSH Terms
Calcitonin Gene-Related Peptide
Eye / innervation*
Fluorescent Antibody Technique
Ganglia, Parasympathetic / metabolism
Guinea Pigs
Nerve Endings / metabolism
Nerve Fibers / metabolism
Neuropeptides / metabolism
Sincalide / metabolism*
Substance P / metabolism*
Trigeminal Ganglion / metabolism*
Trigeminal Nerve / metabolism*
Grant Support
Reg. No./Substance:
0/Neuropeptides; 25126-32-3/Sincalide; 33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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